The first example of trimethylsilyl methylenenitronate reacting with aldehydes under an apparent Mukaiyama nitro-aldol reaction
Trimethylsilyl methylenenitronate reacts with both aliphatic and aromatic aldehydes in the presence of catalytic amounts of scandium(III) triflate to form the Henry reaction products in low (25%) to good yields (77%). This is the first example of this silyl nitronate undergoing a nitro-aldol reaction under an acid environment.
Mukaiyama nitro-aldol , 1,2-Nitroalcohol , Henry reaction , Silyl nitronate , Scandium triflate
MacDonald, F. K., Carneiro, K. M. M., & Pottie, I. R. (2011). The first example of trimethylsilyl methylenenitronate reacting with aldehydes under an apparent Mukaiyama nitro-aldol reaction. Tetrahedron Letters, 52(8), 891–893. doi:10.1016/j.tetlet.2010.12.056