Cognitive Event-Related Potentials in Young Adults With Cerebral Palsy: A Proof-of-Concept Study
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Date
2024
Authors
Lackner, Christine L.
Gorter, Jan Willem
Segalowitz, Sidney J.
MyStory Study Group
Journal Title
Journal ISSN
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Publisher
Sage
Abstract
Cerebral palsy (CP) is a movement and posture disorder often accompanied by cognitive difficulties which can be assessed
using event-related potentials (ERPs), an often-overlooked tool in this population. Here we describe our assessment protocol,
examine its feasibility, and validate the use of single-subject ERP analyses in adolescents and young adults with CP, an analysis
approach which recognizes the heterogeneity of the clinical population. This study involved a final sample of 9 adolescents/young
adults with CP participating in the “MyStory” study (age range 16-29 years, Mage = 25.0 years; 6 female; Gross Motor Function
Classification System level I [n = 4], II [n = 2], III [n = 1], IV [n = 1], and V [n = 1]). ERP components were elicited over medial
prefrontal and central cortex (error- and correct-related negativities [ERN/CRN], error-positivity [Pe], N100, P200, N200,
P300), as well as those generated over occipital cortex (P100, N170). Group and single-subject ERP statistics were computed
for ERPs recorded over both areas. Using recently developed data analysis methods (independent components analysis and
robust bootstrapped single-subject statistics), we measured the number of participants demonstrating significant condition
differences at the timing of each ERP component of interest. We demonstrate good validity for ERPs recorded during 2 of
our 3 tasks eliciting frontal activation (eg, 4 of 6 participants with usable data showed a significant single-subject medial frontal
negativity condition difference in a context-switching task) and good validity for ERPs derived from a task engaging occipital
regions (eg, 8 of 9 participants each showed a significant N170 face-object condition effect).
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Citation
Lackner, C., Gorter, J. W., Segalowitz, S. J., & MyStory Study Group. (2023). Cognitive event-related potentials in young adults with cerebral palsy: A proof of concept study. Clinical EEG and Neuroscience, 55(1), 64-75. 10.1177/1550059420977318